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The Key Role of Diagnostic Imaging in Early HFpEF

Hidenori Yaku1, Sanjiv J Shah1

  • 1Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

JACC. Cardiovascular Imaging
|July 31, 2025
PubMed

Insights

Early detection of heart failure with preserved ejection fraction (HFpEF) is vital for timely intervention. This review focuses on identifying early-stage HFpEF, particularly when symptoms are subtle, to reduce the population

Area of Science:

  • Cardiology
  • Medical Diagnostics
  • Public Health

Background:

  • Heart failure with preserved ejection fraction (HFpEF) is a common and serious condition affecting over half of heart failure patients.
  • Early identification of stage C HFpEF is crucial for prompt diagnosis and intervention.
  • Detecting early HFpEF can be challenging, especially without obvious signs of fluid overload or only exercise-induced elevated left atrial pressure.

Purpose of the Study:

  • To provide a comprehensive overview of early-stage HFpEF.
  • To detail the epidemiology, pathogenesis, diagnostic approaches, and management strategies for early HFpEF.
  • To emphasize the role of diagnostic imaging in identifying early HFpEF.

Main Methods:

  • Review of current literature on HFpEF epidemiology, pathogenesis, and diagnostics.
  • Focus on diagnostic imaging techniques for early HFpEF detection.
  • Analysis of management strategies for early-stage HFpEF.

Main Results:

  • Early HFpEF presents diagnostic challenges, often requiring specific clinical suspicion.
  • Diagnostic imaging plays a key role in identifying subtle signs of early HFpEF.
  • Understanding early HFpEF is essential for reducing the burden of advanced disease.

Conclusions:

  • Prompt diagnosis and intervention are critical for patients with early-stage HFpEF.
  • Advanced diagnostic imaging techniques are valuable for detecting early HFpEF.
  • Further research and awareness are needed to effectively manage early HFpEF and mitigate its impact.

Keywords:
exercise stress testheart failure with preserved ejection fractionhemodynamicsmultimodality imaging

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