Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

5.7K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.7K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

4.8K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
4.8K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.3K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.3K
Lineage Commitment01:21

Lineage Commitment

3.1K
Commitment is the  process whereby stem cells:
3.1K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.3K
Erythropoiesis01:14

Erythropoiesis

4.8K
Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clones in blood and stratified epithelial cells, and their drivers.

Proceedings of the Japan Academy. Series B, Physical and biological sciences·2025
Same author

Romiplostim with ciclosporin A in patients with aplastic anaemia naïve to immunosuppressive therapy: A phase 2/3 study.

British journal of haematology·2025
Same author

Comparison of severe aplastic anaemia and lower risk hypoplastic myelodysplastic neoplasms: Critical role of megakaryocyte count in distinguishing aplastic anaemia from myelodysplastic neoplasms.

British journal of haematology·2025
Same author

Genetic analysis of myeloid neoplasms with der(1;7)(q10;p10).

Leukemia·2024
Same author

Association between microenvironment-related genes and prognosis of primary central nervous system lymphoma.

EJHaem·2024
Same author

Cardiac Reprogramming and Gata4 Overexpression Reduce Fibrosis and Improve Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction.

Circulation·2024

Related Experiment Video

Updated: Sep 13, 2025

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

12.9K

Recent progress in clonal hematopoiesis: expanding the concept.

Shigeru Chiba1,2

  • 1Division of Stem Cell Therapy, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan. schiba-t@md.tsukuba.ac.jp.

International Journal of Hematology
|July 31, 2025
PubMed
Summary

Clonal hematopoiesis (CH), common in aging, links stem cell mutations to diseases. CH increases mortality risk, particularly from cardiovascular and inflammatory conditions, acting as a biomarker and therapeutic target.

Keywords:
Clonal hematopoiesisHematopoietic stem cellMutation

More Related Videos

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture
09:32

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture

Published on: May 8, 2018

8.7K
In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy
17:08

In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy

Published on: August 6, 2014

13.2K

Related Experiment Videos

Last Updated: Sep 13, 2025

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

12.9K
Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture
09:32

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture

Published on: May 8, 2018

8.7K
In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy
17:08

In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy

Published on: August 6, 2014

13.2K

Area of Science:

  • Hematology
  • Genetics
  • Immunology
  • Gerontology

Background:

  • Clonal hematopoiesis (CH) is an age-related phenomenon involving somatic mutations in hematopoietic stem cells.
  • Initially linked to hematologic neoplasms, CH now connects to non-malignant diseases and increased all-cause mortality.
  • Mutations in DNMT3A, TET2, and ASXL1 drive clonal expansion, impacting epigenetic regulation and immune signaling.

Purpose of the Study:

  • To explore the natural history, genetic basis, and inflammatory manifestations of CH.
  • To understand CH's role as a biomarker and potential therapeutic target in aging populations.
  • To highlight CH's implications beyond hematologic malignancies, as exemplified by VEXAS syndrome.

Main Methods:

  • Review of longitudinal studies on clonal growth dynamics.
  • Analysis of germline variant influence on somatic selection.
  • Examination of genetic underpinnings of CH, including frequent mutations (DNMT3A, TET2, ASXL1) and specific syndromes (VEXAS).

Main Results:

  • CH is a significant contributor to increased all-cause mortality, especially via cardiovascular and inflammatory diseases.
  • Somatic mutations in CH alter epigenetic regulation and immune signaling, promoting clonal expansion.
  • Germline variants play a role in somatic selection and clonal expansion dynamics.

Conclusions:

  • Clonal hematopoiesis represents an intermediate biological state with broad clinical implications.
  • CH serves as both a critical biomarker and a potential therapeutic target in aging.
  • Understanding CH is crucial for managing age-related diseases and mortality.