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Targeting JAK-STAT in macrophage activation syndrome-no MAS!

Paresh P Kulkarni1, Keith R McCrae1

  • 1Cleveland Clinic.

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|July 31, 2025
PubMed
Abstract

No abstract available in PubMed .

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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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