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Related Experiment Video

Updated: Sep 13, 2025

In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis

In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis

Published on: August 4, 2011

High-Speed Intravascular Near-Infrared Fluorescence-Ultrasound Imaging In Vivo.

Philipp Rauschendorfer, Andrew Thrapp, Abhishek Srinivas

IEEE Transactions on Bio-Medical Engineering

|July 31, 2025

Summary

This summary is machine-generated.

This study introduces an enhanced near-infrared fluorescence-intravascular ultrasound (NIRF-IVUS) system, improving imaging speed and catheter durability for atherosclerosis detection. The advanced NIRF-IVUS system successfully visualizes arterial inflammation and early plaques at clinical speeds.

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Last Updated: Sep 13, 2025

In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis

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Published on: February 5, 2022

Area of Science:

Cardiovascular Imaging
Biomedical Engineering
Molecular Imaging

Background:

Near-infrared fluorescence (NIRF) combined with intravascular ultrasound (IVUS) shows potential for atherosclerosis imaging.
Clinical translation has been limited by long acquisition times, image distortions, and catheter durability issues.

Purpose of the Study:

To develop and evaluate a next-generation NIRF-IVUS system with improved speed and catheter design.
To assess the system's ability to maintain image quality and detect molecular markers of atherosclerosis at high speeds.

Main Methods:

Developed a novel NIRF-IVUS system featuring a high-speed motor drive unit and a 3.0 French catheter with enhanced durability.
Evaluated system performance in phantoms and in vivo using rabbit models, assessing imaging speed, resolution, stability, and molecular imaging capabilities.

Main Results:

Achieved a sixfold increase in imaging speed (30 FPS, 6 mm/s pullback) while preserving key NIRF-IVUS specifications.
Demonstrated successful in vivo molecular imaging of stent-induced arterial inflammation and early plaque detection in rabbit aortas at clinical speeds.
Observed similar target-to-background ratios for NIRF imaging at both low and high speeds, indicating preserved sensitivity.

Conclusions:

The improved NIRF-IVUS system enables high-speed molecular imaging of atherosclerosis, surpassing standalone IVUS capabilities.
This advancement supports the clinical translation of NIRF-IVUS technology for enhanced cardiovascular diagnostics.