Interacting and joint effects of type of menopause and age at menopause on the likelihood of frailty and the mediating role of age at menopause in older women: A population-based analysis from NHANES 1999-2018
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View abstract on PubMed
Summary
This summary is machine-generated.Surgical menopause increases frailty risk in older women, with age at menopause mediating over 26% of this association. Early menopause combined with surgical menopause further elevates frailty odds.
Area Of Science
- Gerontology
- Reproductive Health
- Public Health
Background
- Menopause, particularly surgical menopause, is a critical transition in women's health.
- Frailty is a significant geriatric syndrome associated with adverse health outcomes.
- Understanding the interplay between menopause and frailty is crucial for healthy aging.
Purpose Of The Study
- To investigate the association between surgical menopause and frailty in older women.
- To examine the mediating role of age at menopause in the surgical menopause-frailty relationship.
- To assess the interaction effects of surgical menopause and age at menopause on frailty.
Main Methods
- Analysis of 7462 women aged ≥60 from the National Health and Nutrition Examination Survey (NHANES).
- Frailty assessed using a 49-item frailty index; diagnosis if index score > 0.21.
- Survey-weighted logistic regression, mediation, and interaction analyses were employed.
Main Results
- Surgical menopause was associated with a 1.44 odds ratio for frailty compared to natural menopause.
- Age at menopause mediated 26.4% of the association between surgical menopause and frailty.
- Joint odds ratio for surgical and early menopause was 1.59 for frailty.
Conclusions
- Surgical menopause is significantly linked to increased frailty likelihood in postmenopausal women.
- Age at menopause plays a substantial mediating role in this association.
- No significant interactions were found between type of menopause and age at menopause on frailty.
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