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Related Concept Videos

Major Hormones and Their Functions01:27

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Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
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Pituitary disorders in pregnancy.

Darran Mc Donald1, Maria Tomkins1, Michael W O'Reilly1

  • 1Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland; Academic Department of Endocrinology, Beaumont Hospital, RCSI Smurfit Building, Dublin, Ireland.

Clinical Medicine (London, England)
|July 31, 2025
PubMed
Summary

Managing pituitary disorders in pregnancy requires careful hormone adjustment and monitoring. Early recognition of pregnancy-related pituitary conditions is vital for maternal and fetal health.

Keywords:
FertilityHypopituitarismMaternal healthPituitary disordersPregnancy

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Area of Science:

  • Endocrinology
  • Maternal Medicine
  • Reproductive Technology

Background:

  • Assisted reproductive technologies (ART) enable more women with hypopituitarism to conceive.
  • Pregnancy induces significant physiological changes in the pituitary gland.
  • Existing hormone replacement therapies require adjustments during pregnancy.

Purpose of the Study:

  • To outline the challenges and management strategies for pituitary disorders during pregnancy.
  • To emphasize the importance of multidisciplinary collaboration for optimal outcomes.
  • To highlight the need for prompt recognition of pregnancy-associated pituitary conditions.

Main Methods:

  • Review of current literature on pituitary disorders in pregnancy.
  • Analysis of physiological changes during pregnancy affecting pituitary function.
  • Discussion of hormone replacement therapy adjustments.
  • Emphasis on clinical and biochemical monitoring protocols.

Main Results:

  • Women with hypopituitarism may experience higher rates of miscarriage, labor induction, and cesarean sections.
  • Some pituitary disorders, like lymphocytic hypophysitis and Sheehan's syndrome, can arise during or after pregnancy.
  • Close monitoring and collaborative care are crucial for successful pregnancy management.

Conclusions:

  • Effective management of pituitary disorders in pregnancy necessitates individualized hormone replacement adjustments.
  • Vigilance for pregnancy-specific pituitary conditions is essential for preventing severe maternal and fetal complications.
  • Multidisciplinary collaboration ensures optimal outcomes for pregnant individuals with hypopituitarism.