Related Experiment Video
Updated: Sep 13, 2025
Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
Published on: January 19, 2024
Microneedling radiofrequency followed by topical exosome application therapy for pattern hair loss: A scoping review
Ioannis-Alexios Koumprentziotis1, Eleni Kroumpouzos2, Shohreh Delavar3
1First Department of Dermatology and Venereology, Medical School, "Andreas Sygros" Hospital for Skin Diseases, National and Kapodistrian University of Athens, Athens, Greece.
Abstract:
Microneedling radiofrequency (MNRF) and exosome therapies have recently garnered attention as potential treatments for pattern hair loss (PHL). This study aimed to conduct a scoping review of these treatments and present a series of patients with PHL treated with MNRF followed by topical exosome application therapy. We searched the PubMed, Google Scholar, and Cochrane databases for relevant articles regarding MNRF and exosome treatments for PHL. Our search yielded two studies on MNRF and nine studies on exosome therapy, all of which demonstrated positive effects on hair regrowth. One of these studies specifically focused on MN combined with exosome therapy. In our current study, we prospectively evaluated the efficacy and safety of MNRF followed by topical exosome application in 20 patients (median age, 46 years), comprising 16 men and four women, with PHL. Clinical evaluations were conducted using macroscopic photographs and digital image analysis with a trichoscopy device at baseline and then again at three, six, and nine months after treatment. The median followup duration was 10 months. Our results revealed significant increases in mean hair density and diameter, along with high patient satisfaction. No adverse events were reported. The treatment response was found to be independent of sex and the severity of PHL. Overall, this study underscores the potential therapeutic benefits of the MNRF followed by topical exosome application therapy. Randomized controlled trials, however, are needed to confirm the efficacy of this therapy and to determine the optimal treatment parameters.
Insights
Microneedling radiofrequency (MNRF) combined with exosome therapy shows promise for pattern hair loss (PHL). This treatment significantly increased hair density and diameter, with high patient satisfaction and no reported adverse events.
Area of Science:
- Dermatology and Regenerative Medicine
- Hair Follicle Biology
- Aesthetic Medicine
Background:
- Pattern hair loss (PHL), or androgenetic alopecia, is a common condition with limited FDA-approved treatments (minoxidil, finasteride) that have potential side effects.
- Emerging therapies like microneedling radiofrequency (MNRF) and exosome therapy offer novel approaches for hair regrowth.
- Exosomes promote hair follicle regeneration via signaling pathways, while MNRF stimulates regrowth through controlled thermal injury.
Purpose of the Study:
- To conduct a scoping review of MNRF and exosome therapies for PHL.
- To prospectively evaluate the efficacy and safety of MNRF followed by topical exosome application in patients with PHL.
Main Methods:
- A literature search was performed on PubMed, Google Scholar, and Cochrane databases for MNRF and exosome treatments for PHL.
- Twenty patients with PHL (16 male, 4 female) received MNRF followed by topical exosome application.
- Clinical evaluations included macroscopic photographs and digital image analysis using a trichoscopy device at baseline and 3, 6, and 9 months post-treatment.
Main Results:
- Scoping review identified studies showing positive effects of MNRF and exosome therapy on hair regrowth.
- MNRF followed by topical exosome application resulted in significant increases in mean hair density and diameter.
- High patient satisfaction was reported, with no adverse events observed; treatment response was independent of sex or PHL severity.
Conclusions:
- The combination of MNRF and topical exosome application demonstrates therapeutic potential for pattern hair loss.
- This combined therapy appears safe and effective, improving hair density and diameter with high patient satisfaction.
- Further randomized controlled trials are necessary to confirm efficacy and establish optimal treatment parameters.
