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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Related Experiment Video

Updated: Sep 13, 2025

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
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Invasive Candida infections in solid organ transplant recipients between 2008 and 2020.

Lilly Meyer1, Jaromil Frossard2, Peter W Schreiber1

  • 1Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|July 31, 2025
PubMed
Summary

Invasive candidiasis (IC) affects 4.3% of solid organ transplant recipients (SOTr), with decreasing incidence over time. Mortality remains high, particularly for liver and heart transplant patients and those with candidemia.

Keywords:
candidemiaepidemiologyinvasive candidiasisoutcomessolid organ transplant recipients

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Area of Science:

  • Infectious Diseases
  • Transplant Medicine
  • Epidemiology

Background:

  • Data on invasive candidiasis (IC) in solid organ transplant recipients (SOTr) are scarce.
  • IC poses a significant threat to SOTr, impacting their long-term outcomes.

Purpose of the Study:

  • To describe the epidemiology and outcomes of IC in SOTr.
  • To analyze trends in IC incidence and associated mortality.
  • To inform future prophylactic strategies for SOTr.

Main Methods:

  • Retrospective multicenter cohort study.
  • Utilized data from the Swiss Transplant Cohort Study (2008-2020).
  • Analyzed 4755 SOTr, identifying 262 episodes of IC.

Main Results:

  • The 1-year cumulative incidence of IC was 2.8%, showing a decreasing trend over time.
  • Intra-abdominal infections were more common than candidemia.
  • All-cause 12-week mortality was 23.5%, with higher rates in liver and heart transplant recipients and those with candidemia.

Conclusions:

  • Invasive candidiasis incidence is decreasing but remains high in SOTr.
  • Mortality rates are substantial, especially in specific transplant types and with candidemia.
  • Findings support the need for enhanced prophylactic and therapeutic strategies in SOTr care.