Predictive factors for failure in patients with N1b papillary thyroid carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.Predictive factors for papillary thyroid carcinoma failure include age, positive margins, number of positive nodes, and extracapsular extension. Patients over 55 years old face higher failure risks and lower survival rates.
Area Of Science
- Oncology
- Head and Neck Surgery
- Pathology
Background
- Papillary thyroid carcinoma (PTC) with lateral neck lymph node metastases (N1b) presents unique treatment challenges.
- Identifying factors predicting treatment failure is crucial for optimizing patient outcomes.
Purpose Of The Study
- To evaluate predictive factors for treatment failure in patients with N1b papillary thyroid carcinoma.
- To assess the impact of patient age and clinicopathological features on treatment outcomes.
Main Methods
- Retrospective analysis of 97 patients with N1b PTC treated between 2008-2021.
- Inclusion criteria: lateral neck lymph node metastases, thyroidectomy, and neck dissection.
- Statistical analysis to identify predictors of failure and survival.
Main Results
- Twenty percent of patients experienced treatment failure.
- Age, number of positive nodes, extracapsular extension, and positive margins were significant predictors of failure.
- Patients over 55 years old had higher failure rates and lower recurrence-free survival.
Conclusions
- Age, positive margins, nodal yield, and extracapsular extension are key predictors of treatment failure in N1b PTC.
- Younger patients (≤55 years) with advanced regional disease demonstrate better recurrence-free survival and overall survival.
- Age is a critical factor influencing outcomes in PTC with lateral neck metastasis.
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