Vitamin D immune modulation of the anti-inflammatory effects of HDL-associated proteins

Vitamin D is a crucial element in bone metabolism and plays a role in innate immunity and inflammation suppression. Deficiency in this vitamin leads to disturbances in many biological functions, including the lipid profile. The decrease in HDL levels is associated with disruptions in its function and dynamic modifications in its components, such as apolipoproteins, including ApoM, ApoA-1, and ApoD. Consequently, the anti-inflammatory potential of HDL and HDL-associated proteins is reduced, resulting in heightened inflammation. However, the relationship between modifications in lipid profile, apolipoproteins, inflammation, and vitamin D remains unclear. This review highlights the connection between vitamin D status and its possible effects on the lipid profile, specifically HDL-associated proteins.