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Related Concept Videos

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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Related Experiment Video

Updated: Sep 13, 2025

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
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Hybrid optimization enabled Eff-FDMNet for Parkinson's disease detection and classification in federated learning.

Sangeetha Subramaniam1, Umarani Balakrishnan2

  • 1Department of Information Technology, Kongunadu College of Engineering and Technology (Autonomous), Trichy, India.

Network (Bristol, England)
|August 1, 2025
PubMed
Summary

This study introduces a new AI framework for early Parkinson's Disease (PD) detection and classification. The FedL_WSSO based Eff-FDMNet achieves high accuracy, improving patient diagnosis and outcomes.

Keywords:
Parkinson‘s diseasefederated learningmagnetic resonance imagingwater wheel plant optimization

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Area of Science:

  • Neuroscience
  • Artificial Intelligence
  • Medical Imaging

Background:

  • Parkinson's Disease (PD) is a progressive neurodegenerative disorder.
  • Early diagnosis is critical for effective symptom management and slowing disease progression.

Purpose of the Study:

  • To propose a novel framework, FedL_WSSO based Eff-FDMNet, for accurate PD detection and classification.
  • To leverage federated learning and advanced deep learning models for improved diagnostic reliability.

Main Methods:

  • Image preprocessing using Gaussian filters and augmentation.
  • Feature extraction followed by PD detection using ShCNN-Fuzzy-ZFNet.
  • PD classification via WSSO-trained Eff-FDMNet with CAViaR-based server updates.

Main Results:

  • Achieved highest accuracy of 0.927.
  • Obtained mean average precision of 0.905.
  • Reported lowest false positive rate (FPR) of 0.082, loss of 0.073, MSE of 0.213, and RMSE of 0.461.

Conclusions:

  • The developed FedL_WSSO based Eff-FDMNet framework demonstrates high accuracy and low error rates for PD detection.
  • This potent framework has the potential to enhance patient outcomes through reliable and personalized diagnosis.