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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Oncocytic salivary gland carcinomas
Ziyad Alsugair1,2, Anne Champagnac3, Nazim Benzerdjeb1,4,5
1Department of Pathology, Institut de Pathologie Multisite, Hospices Civils de Lyon, Lyon Sud University Hospital, Pierre-Bénite, France.
Oncocytic salivary gland carcinomas are rare, diverse tumors with distinct molecular profiles. Accurate classification requires integrated histopathology, immunohistochemistry, and molecular diagnostics for improved patient outcomes.
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- Oncocytic carcinomas of salivary glands are rare malignancies.
- Characterized by granular eosinophilic cytoplasm due to abundant mitochondria.
- Diverse group with varying morphological patterns.
Purpose of the Study:
- Provide a comprehensive overview of oncocytic salivary gland carcinomas.
- Categorize these tumors by morphological patterns: monophasic, biphasic, and complex.
- Emphasize the role of integrated diagnostics for accurate classification.
Main Methods:
- Review of existing literature on oncocytic salivary gland carcinomas.
- Categorization based on morphological patterns (monophasic, biphasic, complex).
- Discussion of immunohistochemical profiles and genetic alterations.
Main Results:
- Monophasic entities include oncocytic intraductal carcinoma (OIDC), oncocytic salivary duct carcinoma (OSDC), acinic cell carcinoma (ACC), and secretory carcinoma (SC).
- Biphasic tumors like oncocytic epithelial-myoepithelial carcinoma (OEMC) and oncocytic adenocarcinoma not otherwise specified (OANOS) present diagnostic challenges.
- Complex-pattern tumors, such as oncocytic mucoepidermoid carcinoma (OMEC), require advanced molecular diagnostics.
Conclusions:
- Accurate classification relies on integrated histopathology, immunohistochemistry, and molecular profiling.
- Molecular heterogeneity and clinicopathologic nuances are crucial for diagnosis and prognosis.
- Some entities remain provisional, awaiting widespread transcriptomic tools for definitive classification.
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