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Updated: Sep 13, 2025

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Skin-Conformal Multifunctional Microfluidic Colorimetric Detection Device for Multiplexed Sweat Analysis.

Fang Li1, Nuotong Shen1, Limin Zhang1

  • 1Anhui Province Key Laboratory of Value-Added Catalytic Conversion and Reaction Engineering, Anhui Province Engineering Research Center of Flexible and Intelligent Materials, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, Anhui 230009, China.

ACS Sensors
|August 1, 2025
PubMed
Summary
This summary is machine-generated.

A new flexible device analyzes sweat in real-time for health monitoring. This noninvasive, low-cost wearable measures multiple sweat indicators, offering convenient and early disease detection.

Keywords:
Colorimetric assayMicrofluidic chipMultiplexed analysisSweat analysisWearable sensor

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Wearable Technology

Background:

  • Real-time, noninvasive sweat analysis offers economical and convenient health monitoring.
  • Early disease diagnosis can be facilitated by continuous physiological data.
  • Existing methods often lack in situ capabilities or multi-analyte detection.

Purpose of the Study:

  • To develop a flexible, skin-interfaced microfluidic device for in situ sweat collection and multi-index analysis.
  • To enable simultaneous measurement of key sweat parameters for comprehensive health assessment.
  • To create a user-friendly and low-cost platform for wearable sweat diagnostics.

Main Methods:

  • Fabrication of a multifunctional microfluidic device with optimized design and multilayer layout.
  • Integration of colorimetric chemical techniques for sweat component detection.
  • Inclusion of capillary bursting valves (CBVs) for controlled sweat transport and prevention of cross-contamination.

Main Results:

  • The device successfully measures urea, chloride ions, magnesium ions, pH, skin temperature, sweat volume, and sweat loss rate.
  • Detection results are easily readable via naked eye or smartphone application.
  • Demonstrated practical application potential through successful testing in healthy volunteers.

Conclusions:

  • A simple, low-cost, flexible, and convenient sweat analysis device has been developed.
  • The device enables in situ, noninvasive, and intelligent wearable measurements of multiple sweat components.
  • This technology paves the way for advanced personal health monitoring and early disease diagnostics.