Cannabis use disorder and five-year risk of oral cancer in a multicenter clinical cohort
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View abstract on PubMed
Summary
This summary is machine-generated.Cannabis use disorder (CUD) is linked to a threefold increase in oral cancer risk. This study highlights the need to assess long-term oncologic risks associated with problematic cannabis use.
Area Of Science
- Oncology
- Public Health
- Addiction Medicine
Background
- Cannabis use disorder (CUD) prevalence is rising in the US.
- Long-term health effects of CUD are not well-understood.
- Shared carcinogens in cannabis and tobacco suggest potential oral cancer risk.
Purpose Of The Study
- To assess the association between CUD and five-year oral cancer risk.
- To evaluate oral cancer incidence in a large clinical cohort with and without CUD.
Main Methods
- Retrospective cohort study of adults screened for drug use disorders.
- Analysis of clinical records from six academic medical centers.
- Five-year follow-up for oral cancer diagnoses (lip or tongue) after CUD diagnosis.
Main Results
- Among 45,129 patients, 2.1% developed CUD.
- Oral cancer incidence was 0.74% in the CUD group vs. 0.23% in non-CUD patients.
- CUD was associated with a threefold increased risk of oral cancer (adjusted OR 3.25).
Conclusions
- CUD is significantly associated with increased oral cancer risk over five years.
- Findings underscore the importance of evaluating long-term oncologic risks of problematic cannabis use.
- Clinical assessment of oral cancer risk should consider CUD status.
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