Comprehensive review of mouse models for studying cancer-related fatigue: Methods, findings and future directions...

Cancer-related fatigue (CRF) is one of the most prevalent and debilitating symptoms experienced by patients with cancer, significantly impacting their quality of life. Currently, the precise mechanisms underlying the onset of this fatigue remain poorly understood, and there is a notable lack of effective pharmacological treatments to alleviate it. Therefore, establishing a reliable and stable mouse model of CRF is essential for advancing research in this important area. The present study systematically reviewed various methods for inducing CRF in mice, including tumor-bearing models, chemotherapy and localized irradiation, either used alone or in combination. The advantages and disadvantages of each of these models were analyzed, providing researchers with valuable insights and references for selecting the most appropriate mouse model of CRF for their specific studies.