Clinical significance of altered expression of mitochondrial genome-derived LncRNA LIPCAR in colorectal cancer
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.LIPCAR expression is significantly downregulated in colorectal cancer (CRC) tissues, suggesting its role as a tumor suppressor and potential biomarker. Further research is needed to validate these findings for clinical application.
Area Of Science
- Molecular biology
- Oncology
- Genomics
Background
- Colorectal cancer (CRC) prevalence and mortality are increasing globally.
- Understanding CRC molecular pathophysiology is crucial for developing diagnostic and therapeutic markers.
- Mitochondrial transcripts, including long non-coding RNAs (lncRNAs), play a role in cancer development.
Purpose Of The Study
- To investigate the expression profile of LIPCAR in colorectal cancer (CRC).
- To correlate LIPCAR expression with clinicopathological parameters in CRC patients.
- To evaluate LIPCAR as a potential diagnostic biomarker for CRC.
Main Methods
- Analysis of 40 pairs of CRC tissues (tumor and adjacent non-tumor samples).
- Real-time PCR with SYBR green to quantify LIPCAR expression.
- Receiver Operating Characteristic (ROC) curve analysis to assess diagnostic potential.
Main Results
- LIPCAR expression was significantly downregulated in CRC tumor tissues compared to non-tumor tissues (p<0.05).
- No significant correlation was found between decreased LIPCAR expression and clinicopathological parameters.
- ROC analysis indicated LIPCAR as a potential biomarker with an AUC of 0.75 (sensitivity 87.5%, specificity 57.5%).
Conclusions
- Downregulation of LIPCAR suggests its involvement in CRC pathogenesis, potentially acting as a tumor suppressor.
- LIPCAR may serve as a valuable clinical biomarker for CRC detection.
- Further in vitro and in vivo functional studies are required to validate these findings.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...