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Updated: Sep 13, 2025

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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miRNA Expression Analyses in Prostate Cancer Clinical Tissues

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The role and clinical potential of RNA modifications in bladder cancer

Yuqing Wu1, Fenghao Zhang1, Yufan Ying1

  • 1Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.

Bladder (San Francisco, Calif.)
|August 1, 2025
PubMed
Abstract

Insights

RNA modifications, including N6-methyladenosine, are crucial in bladder cancer (BC) progression and immune evasion. Targeting these modifications offers new avenues for BC precision medicine and overcoming drug resistance.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Bladder cancer (BC) is a heterogeneous malignancy with complex behaviors, challenging effective treatment.
  • RNA modifications, such as N6-methyladenosine (m6A), 1-methyladenosine, 5-methylcytosine, N4-acetylcytidine, and 7-methylguanosine, play significant roles in BC cell proliferation, migration, drug resistance, and immune evasion.

Purpose of the Study:

  • To comprehensively review the regulatory mechanisms and biological impacts of RNA modifications in bladder cancer.
  • To focus on the interplay between RNA modifications and immune evasion in BC.
  • To explore the emerging roles of RNA modifications in precision medicine for bladder cancer.

Main Methods:

  • Literature review of existing research on RNA modifications in bladder cancer.
  • Analysis of regulatory mechanisms and biological impacts of specific RNA modifications.
  • Synthesis of findings related to immune evasion and precision medicine applications.

Main Results:

  • RNA modifications significantly influence key BC cellular processes including proliferation, migration, drug resistance, and immune evasion.
  • The interplay between RNA modifications and immune evasion presents novel therapeutic strategies.
  • RNA modifications show potential as diagnostic markers, prognostic indicators, and therapeutic targets in BC.

Conclusions:

  • RNA modifications are critical regulators of bladder cancer progression and immune evasion.
  • Targeting RNA modification pathways presents a promising strategy to enhance current BC treatments and overcome drug resistance.
  • Further research into RNA modifications will advance BC precision medicine.
Keywords:
Bladder cancerDrug resistancePrognosisRNA modificationsm6A methylation

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