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Midterm Outcomes of Pediatric Mitral Valvuloplasty for Moderate to Severe Mitral Valve Regurgitation and Associated

Hongyuan Fu1, Aijun Liu1, Ming Yang1

  • 1Pediatric Cardiovascular Center, Capital Medical University Affiliated Anzhen Hospital, Beijing, China.

Texas Heart Institute Journal
|August 1, 2025
PubMed

Insights

Mitral valvuloplasty effectively treats pediatric mitral valve regurgitation, showing significant improvement and low mortality. Early intervention is key to prevent long-term valve deterioration in children.

Area of Science:

  • Cardiology
  • Pediatric Cardiac Surgery
  • Interventional Cardiology

Background:

  • Mitral valve regurgitation (MVR) in children often requires intervention.
  • Mitral valvuloplasty is a primary treatment option for pediatric MVR.
  • Identifying risk factors for MVR progression post-procedure is crucial.

Purpose of the Study:

  • To identify risk factors for mitral valve regurgitation progression after valvuloplasty in pediatric patients.
  • To evaluate the effectiveness of mitral valvuloplasty in treating pediatric MVR.
  • To assess long-term outcomes and prognosis following the procedure.

Main Methods:

  • Retrospective, single-center study of 137 pediatric patients with moderate to severe MVR.
  • Kaplan-Meier analysis for freedom from MVR deterioration and cardiovascular death.
  • Univariate and multivariate Cox regression to identify independent risk factors.

Main Results:

  • Mitral valvuloplasty significantly reduced MVR severity (P < .001).
  • Midterm follow-up showed 89.4% freedom from MVR worsening and 97.5% freedom from cardiovascular death.
  • Independent risk factors for deterioration included body weight, LV end-diastolic diameter, LV ejection fraction, and cardiopulmonary bypass time.

Conclusions:

  • Mitral valvuloplasty offers low mortality and positive long-term outcomes for pediatric MVR.
  • Early, aggressive treatment is recommended to mitigate late postoperative valve deterioration.
  • Factors like higher body weight and larger ventricular septal defects correlate with worse outcomes.
Abstract

Keywords:
Mitral regurgitationpediatrics

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