Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical Criteria for the Definition of Refractory Septic Shock: A Joint Delphi Consensus from the Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM).

Critical care medicine·2026

Same author

Clinical criteria for the definition of refractory septic shock: a joint Delphi consensus from the Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM).

Intensive care medicine·2026

Same author

Author Correction: Current standard of care for septic shock.

Intensive care medicine·2025

Same author

Current standard of care for septic shock.

Intensive care medicine·2025

Same author

European Society of Intensive Care Medicine Clinical Practice Guideline on fluid therapy in adult critically ill patients: Part 3-fluid removal at de-escalation phase.

Intensive care medicine·2025

Same author

High-Frequency Basal Cell Carcinoma: Demographic, Clinical, and Histopathological Features in a Belgian Cohort.

Journal of clinical medicine·2025

Search research articles

Related Experiment Video

Updated: Sep 13, 2025

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Methylprednisolone and Endothelial Dysfunction in Cardiac Surgery: A Pilot Randomized Trial.

Katarina Winant Halenarova¹, Daniel De Backer², Hassane Njimi¹

¹Department of Intensive Care, Erasme Hospital, Hôpitaux Universitaires de Bruxelles, Brussels, Belgium.

Acta Anaesthesiologica Scandinavica

|August 1, 2025

Summary

A single dose of methylprednisolone did not significantly improve endothelial dysfunction markers in cardiac surgery patients undergoing cardiopulmonary bypass. Further research is needed to explore potential links between glycocalyx damage and vascular reactivity.

Keywords:

cardiac surgery cardiopulmonary bypass endothelial dysfunction flow‐mediated dilation microcirculation

More Related Videos

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Published on: July 7, 2016

Author Spotlight: Enhancing Coronary Artery Revascularization

Author Spotlight: Enhancing Coronary Artery Revascularization

Published on: September 15, 2023

Related Experiment Videos

Last Updated: Sep 13, 2025

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Published on: July 7, 2016

Author Spotlight: Enhancing Coronary Artery Revascularization

Author Spotlight: Enhancing Coronary Artery Revascularization

Published on: September 15, 2023

Area of Science:

Cardiology
Vascular Surgery
Anesthesiology

Background:

Cardiac surgery with cardiopulmonary bypass (CPB) is a model for ischemia-reperfusion injury and endothelial dysfunction.
Endothelial injury manifests as vasoplegia and microcirculatory disturbances.
Corticosteroids may offer protective effects against CPB-induced endothelial dysfunction.

Purpose of the Study:

To evaluate the protective effect of a single methylprednisolone dose on endothelial dysfunction in patients undergoing elective cardiac surgery with CPB.
To assess the impact of methylprednisolone on flow-mediated dilation (FMD), near-infrared spectroscopy (NIRS StO2), and syndecan-1 levels.

Main Methods:

A parallel-group, randomized, controlled single-center trial involving 39 patients scheduled for elective cardiac surgery with CPB.
Patients received either intravenous methylprednisolone or placebo at anesthesia induction.
Primary outcome: endothelial dysfunction assessed by FMD; secondary outcomes: NIRS StO2, syndecan-1 levels, and their correlations.

Main Results:

No significant differences in FMD, NIRS StO2, or syndecan-1 levels were observed between the methylprednisolone and placebo groups post-CPB.
Postoperative FMD measurements also showed no significant difference between the groups.
A significant correlation was found between FMD alteration severity and syndecan-1 levels (r=0.21, p=0.03).

Conclusions:

Methylprednisolone did not significantly mitigate CPB-associated endothelial dysfunction markers in this cohort.
A correlation between syndecan-1 levels and peak arterial dilation suggests a link between glycocalyx damage and vascular reactivity.