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Histone deacetylase 4: A therapeutic target for cardiovascular diseases (Review)

Xiaotong Ma1, Ran Wei1, Anni Song2

  • 1College of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, P.R. China.

International Journal of Molecular Medicine
|August 1, 2025
PubMed

Insights

Histone deacetylase 4 (HDAC4) plays a key role in cardiovascular diseases (CVD) by influencing inflammation, fibrosis, and apoptosis. Understanding HDAC4

Area of Science:

  • Biomedical research
  • Cardiovascular science
  • Molecular biology

Background:

  • Cardiovascular disease (CVD) presents a significant global health challenge.
  • Rising incidence and mortality rates necessitate novel therapeutic strategies.
  • Histone deacetylase 4 (HDAC4) is emerging as a critical factor in CVD pathogenesis.

Purpose of the Study:

  • To review the functional roles of HDAC4 in cardiovascular diseases.
  • To examine the impact of pharmacological agents and physical exercise on HDAC4 expression.
  • To highlight the need for further research into HDAC4's molecular mechanisms in CVD.

Main Methods:

  • Literature review of studies on HDAC4 and CVD.
  • Analysis of HDAC4's regulation of pathophysiological processes (inflammation, fibrosis, apoptosis).
  • Examination of therapeutic interventions affecting HDAC4 expression.

Main Results:

  • HDAC4 influences cardiac hypertrophy, hypertension, and atherosclerosis.
  • HDAC4 modulates key processes including inflammation, fibrosis, and apoptosis in CVD.
  • Pharmacological agents and physical exercise can affect HDAC4 expression.

Conclusions:

  • HDAC4 is a significant regulator in the development and progression of CVD.
  • Further elucidation of HDAC4's molecular mechanisms is crucial for clinical applications.
  • Targeting HDAC4 may offer new avenues for CVD diagnosis and treatment.

Keywords:
cardiovascular diseasesfunctionhistone deacetylase 4mechanism of actiontherapeutic target

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