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A Clinical Consensus Statement on Pulmonary Recurrent Respiratory Papillomatosis.
Nikita Kohli1, Sara I Pai1, Julia Buckingham2
1Yale University School of Medicine, New Haven, Connecticut, USA.
Pulmonary recurrent respiratory papillomatosis (pRRP) is rare, but guidelines for its diagnosis and management are now available. This consensus statement offers best practices for screening, diagnosis, and treatment of pRRP.
Area of Science:
- Pulmonology
- Otolaryngology
- Oncology
- Radiology
Background:
- Pulmonary recurrent respiratory papillomatosis (pRRP) is a rare condition with limited data on its workup and management.
- pRRP affects up to 9% of patients with recurrent respiratory papillomatosis (RRP) and has a significantly increased risk of malignant transformation.
Purpose of the Study:
- To develop evidence-based guidance for the screening, diagnosis, and management of pRRP.
- To establish consensus among multidisciplinary experts on best practices for pRRP.
Main Methods:
- A Delphi method was employed, involving a multidisciplinary expert group and iterative consensus surveys.
- Literature review and rigorous consensus-building discussions were conducted.
Main Results:
- Consensus was achieved on 33 statements covering screening, diagnosis, management, and treatment of pRRP.
- Key recommendations include HPV typing, chest CT for monitoring, biopsy of lesions, multidisciplinary team management, and consideration of systemic therapy.
Conclusions:
- Establishing consensus on best practices for pRRP can reduce treatment variability and guide future research.
- This statement represents the collective expertise of national specialists in managing pRRP.
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