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Related Experiment Video

Updated: Sep 13, 2025

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
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Penile Metastasis from Prostate Cancer: Detection on 18F-PSMA-1007 PET/CT.

Hend Komber1,2, Ayah Nawwar1,3,4, Julie Searle3,2

  • 1University Hospitals Bristol and Weston NHS Foundation Trust, Clinic of Radiology, Bristol, UK.

Molecular Imaging and Radionuclide Therapy
|August 1, 2025
PubMed
Summary

A rare penile metastasis was identified in a prostate cancer patient using PSMA-1007 PET/CT. This finding, though uncommon, is crucial for accurate staging and treatment planning in advanced prostate cancer.

Keywords:
18F-PSMA-1007 positron emission tomography/computed tomographypenile metastasisprostate cancer

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiology

Background:

  • Prostate cancer management relies on accurate staging.
  • Oligometastatic disease requires precise detection for optimal treatment.
  • Prostate-specific membrane antigen (PSMA) PET/CT is a key imaging modality.

Purpose of the Study:

  • To report a rare case of penile metastasis in prostate cancer.
  • To highlight the diagnostic utility of 18F-PSMA-1007 PET/CT.
  • To emphasize the importance of differentiating pathological uptake from urinary activity.

Main Methods:

  • A 74-year-old male patient with prostate cancer and rising PSA was investigated.
  • 18F-PSMA-1007 positron emission tomography/computed tomography (PET/CT) was performed.
  • Detailed review of imaging findings, including the penile region, was conducted.

Main Results:

  • PSMA avid local recurrence, pelvic, retroperitoneal nodal metastases, and skeletal deposits were identified.
  • A rare, small penile metastasis was detected.
  • The finding has implications for prognosis and patient management.

Conclusions:

  • 18F-PSMA-1007 PET/CT can detect rare metastatic sites like penile deposits.
  • Careful interpretation is needed to distinguish true metastasis from urinary excretion.
  • Identification of penile metastasis impacts staging and treatment decisions in advanced prostate cancer.