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Related Concept Videos

Atelectasis II: Pathophysiology01:10

Atelectasis II: Pathophysiology

Atelectasis develops when alveoli lose their air and collapse inward. Because lung tissue is naturally elastic, these air sacs shrink rather than remaining open. Collapsed alveoli are no longer ventilated, reducing their role in gas exchange. Blood flow may continue in these regions, creating a ventilation–perfusion mismatch. Clinical findings include decreased breath sounds, dullness to percussion, reduced chest expansion, and decreased tactile fremitus as sound transmission through collapsed...
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Respiratory System Abnormal Finding I: Inspection and Percussion

Respiratory system abnormalities are a significant concern in healthcare due to their potential to indicate underlying severe conditions like Chronic Obstructive Pulmonary Disease (COPD), asthma, and pneumonia. These abnormalities can often be detected through physical examination methods like inspection and percussion.
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Related Experiment Video

Updated: Jun 16, 2026

Author Spotlight: Development of a Laser-Induced Shock Wave Animal Model Without Tympanic Membrane Perforation
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Published on: March 1, 2024

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Hyperbaric Oxygen and Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-Analysis.

Isaac L Alter1, Mickie Hamiter1,2, Jiying Han3

  • 1Department of Otolaryngology-Head and Neck Surgery, Columbia University Vagelos College of Physicians and Surgeons, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, New York, USA.

The Laryngoscope
|August 1, 2025
PubMed
Summary

Hyperbaric oxygen therapy (HBOT) combined with medical therapy significantly improves hearing recovery in sudden sensorineural hearing loss (SSNHL) patients. This meta-analysis confirms HBOT

Keywords:
hearing losshyperbaric oxygensensorineural hearing loss

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Area of Science:

  • Otolaryngology
  • Neurosurgery
  • Emergency Medicine

Background:

  • Sudden sensorineural hearing loss (SSNHL) presents a significant clinical challenge with profound impacts on affected individuals.
  • Hyperbaric oxygen therapy (HBOT) is a potential treatment for SSNHL, but its efficacy remains debated.

Purpose of the Study:

  • To systematically review and meta-analyze the existing evidence on the effectiveness of HBOT in treating SSNHL.
  • To assess the impact of HBOT, alone or in combination with other therapies, on hearing recovery in SSNHL patients.

Main Methods:

  • A comprehensive literature search was conducted across multiple databases (PubMed, EMBASE, CENTRAL, MEDLINE, Google Scholar, Web of Science, Clinicaltrials.gov) up to May 7, 2025.
  • Data extraction and screening were performed independently by two investigators following PRISMA guidelines.
  • A random-effects model was used to calculate pooled odds ratios (ORs) for hearing recovery.

Main Results:

  • Twenty studies, including 16 RCTs and 4 non-randomized prospective studies, involving 1087 patients receiving HBOT and 600 receiving medical therapy (MT) alone were analyzed.
  • Meta-analysis of ten studies revealed that patients receiving HBOT plus MT had 2.61 times higher odds of hearing recovery compared to MT alone (95% CI 1.86-3.68, p < 0.001).
  • Subgroup analyses demonstrated significantly higher odds of hearing recovery with HBOT when combined with systemic steroids (OR 2.54) or systemic and intratympanic steroids (OR 2.64).

Conclusions:

  • Combining HBOT with medical therapy appears to be beneficial for hearing recovery in individuals diagnosed with SSNHL.
  • Further research is recommended to standardize treatment protocols and improve data reporting for more conclusive findings on HBOT efficacy in SSNHL.