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Related Concept Videos

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Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
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Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
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Endogenous human herpesviruses 6A/B.

Louis Flamand1,2, Jesse Arbuckle3, Pascale Bonnafous4

  • 1Department of Microbiology, Infectious Disease and Immunology, Faculty of Medicine, Université Laval, Québec, Canada.

Journal of Virology
|August 1, 2025
PubMed
Summary
This summary is machine-generated.

Inherited human herpesviruses 6A/6B (eHHV-6A/B) integrate into germline DNA, passed to offspring. This viral DNA may reactivate, causing health issues, necessitating standardized terminology for clarity.

Keywords:
HHV-6eHHV-6endogenous HHV-6human herpesvirus 6iciHHV-6inherited chromosomally integrated HHV-6

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Area of Science:

  • Virology
  • Genetics
  • Human Health

Background:

  • Human herpesviruses 6A and 6B (HHV-6A/B) possess the ability to integrate into the host genome.
  • Germline integration results in inherited viral DNA, termed "endogenous HHV-6A/B (eHHV-6A/B)".
  • This inherited DNA is present in 0.2-3% of the human population and can be transmitted across generations.

Purpose of the Study:

  • To propose standardized nomenclature for HHV-6A/B integrations.
  • To differentiate between germline and somatic integrations of HHV-6A/B.

Main Methods:

  • Review of existing literature on HHV-6A/B integration.
  • Proposal of new terminology based on integration type.

Main Results:

  • Advocacy for the term "endogenous HHV-6A/B (eHHV-6A/B)" for germline-integrated HHV-6A/B.
  • Recommendation to reserve "chromosomally integrated" exclusively for somatic integrations.

Conclusions:

  • Standardized terminology is crucial to reduce confusion in research and clinical settings.
  • Clear distinction between inherited and somatic HHV-6A/B integrations is necessary for accurate health risk assessment.
  • The proposed nomenclature aims to improve communication regarding eHHV-6A/B and its potential health implications.