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Reference values for the total and differential leukocyte count.

O W van Assendelft

    Blood Cells
    |January 1, 1985
    PubMed
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    The National Health and Nutrition Examination Surveys provide valid white blood cell differential counts for the U.S. population since 1971. This study validates these counts using established reference values for all cell types.

    Area of Science:

    • Hematology
    • Public Health Surveillance

    Background:

    • The National Health and Nutrition Examination Surveys (NHANES) have collected extensive health data since 1971.
    • White blood cell (WBC) counts and differential counts are crucial hematological parameters.
    • Validating these counts is essential for accurate population health assessments.

    Purpose of the Study:

    • To discuss the validity of white blood cell differential counts obtained from NHANES.
    • To assess the reliability of NHANES differential count data using reference values.

    Main Methods:

    • Utilizing data collected by the National Health and Nutrition Examination Surveys since 1971.
    • Employing a set of established reference values for all white blood cell types.
    • Analyzing the concordance between NHANES differential counts and reference values.

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    Main Results:

    • NHANES white blood cell differential counts are valid for the U.S. population.
    • The availability of reference values supports the accuracy of differential count data.
    • Established reference values confirm the reliability of NHANES hematological data.

    Conclusions:

    • NHANES provides a valuable and valid resource for U.S. white blood cell differential data.
    • The use of reference values enhances the confidence in NHANES hematological findings.
    • These validated counts are critical for epidemiological studies and public health monitoring.