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Topical 5-Fluorouracil as a Novel Adjuvant Therapy for Ameloblastoma
Jing-Rui Yi1, Gui-Lin Liu2, Qi-Wen Man1,3
1The State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School and Hospital of Stomatology, Wuhan University, Wuhan.
Abstract:
The primary treatment for ameloblastoma is curettage or marsupialization, with a relatively high recurrence. Presently, the authors demonstrate the potential efficacy of topical 5-fluorouracil (5-FU) as a promising treatment modality for ameloblastoma after curettage in 4 cases. Transmission electron microscopy of 5-FU-treated ameloblastoma tissue showed apoptosis within cells. Topical application of 5-FU after curettage efficiently treats ameloblastoma without recurrence within 2 years.
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