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Updated: Sep 13, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Visible-Light-Driven Trifluoroacetylation of Azauracils
Jiangzhen An1, Xi Chen2, Yuankai Zhuang1
1College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.
None:
A novel visible-light-driven method for the trifluoroacetylation of azauracils was reported, utilizing oxygen as the oxidant and a masked trifluoroacetyl reagent as the radical precursor. This eco-friendly approach eliminates the need for expensive catalysts, transition metals, and additional additives, offering a straightforward, efficient, and scalable solution. The method demonstrates excellent functional group tolerance and versatility, making it ideal for late-stage modifications of a wide range of bioactive molecules. This advancement not only improves the synthetic accessibility of trifluoroacetylated compounds but also supports the principles of sustainable chemistry.
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