ZLN005, a PGC-1α transcriptional activator, exacerbates cardiac function following myocardial infarction in a...

Ischemic heart disease, and specifically myocardial infarction (MI), is the leading cause of death worldwide; 25 % of patients with acute MI proceed to heart failure. Myocardial mitochondrial dysfunction has recently been reported to contribute to detrimental cardiac remodeling. Mitochondria are responsible for 90 % of ATP production in the myocardium, and their biosynthesis is dependent on the peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α). In this study, we aimed to clarify the effects of ZLN005, a PGC-1α activator, on MI using in vivo and in vitro models. First, we showed that the expression level of PGC-1α was significantly decreased 7 days after MIin mice. Then, to increase the expression of PGC-1α, we treated mice with ZLN005for 14 days; this treatment significantly increased the ratio of BAX/Bcl-2 expression, a marker of cell death. Using electrocardiograms, we also revealed that treatment with ZLN005 induced a decrease in cardiac function. Mimicking the above in vivo conditions, ZLN005-treated cardiomyocytes under oxygen-glucose deprivation conditions exhibited a decrease in mitochondrial function and ATP production. These results suggested that sustained administration of ZLN005 under ischemia exacerbates the pathogenesis of MI.