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Updated: Sep 13, 2025

A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases
Published on: February 21, 2015
Generation of induced pluripotent stem cells from 8 neurotypical individuals with elevated genetic risk for
Sangho S Myung1, Srinidhi Rao Sripathy2, Brady J Maher3
1Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Abstract:
Schizophrenia (SCZ) is a common and debilitating mental illness characterized by positive and negative symptoms, and impaired cognition. Genome-wide association studies (GWAS) have identified hundreds of genomic regions containing SCZ risk variants. For each individual, a polygenic risk score (PRS) can be derived, which is a metric of genetic susceptibility for SCZ. Here, we report the generation of human induced pluripotent stem cells (hiPSCs) from 8 neurotypical individuals with elevated PRS. These hiPSC lines will be useful to study common variant risk for SCZ and for the generation of isogenic lines containing rare variants associated with SCZ risk.
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