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DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
Published on: September 27, 2019
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Applications of DNA-based nanostructures in immunotherapy
Dandan Li1, Huarui Liu2, Xintong Li1
1Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Advanced Drug Delivery Reviews
|August 1, 2025
Summary
DNA nanostructures offer precise control for immunotherapy applications. This review explores their use in delivering treatments like tumor antigens and immune-regulating agents, discussing future potential.
Area of Science:
- Biotechnology and Nanomedicine
- Immunology and Cancer Therapy
Background:
- DNA's ability to form precise nanostructures with biocompatibility makes it ideal for biomedical applications.
- Self-assembled DNA nanostructures are increasingly used in bio-imaging, diagnostics, and drug delivery.
Purpose of the Study:
- To review recent advancements in DNA-based nanostructures for immunotherapy.
- To explore diverse DNA nanostructures and their roles in various immunotherapeutic strategies.
Main Methods:
- Review of literature on DNA nanostructures (DNA origami, hydrogels, etc.) applied in immunotherapy.
- Analysis of DNA nanostructures for delivering immunotherapeutic agents (adjuvants, antigens, inhibitors, vaccines).
Main Results:
- DNA nanostructures effectively deliver CpG adjuvants, tumor antigens, PD1 inhibitors, mRNA vaccines, and virus antigens.
- These structures can directly modulate immune cells for therapeutic benefit.
Conclusions:
- DNA nanostructures show significant promise for in vivo immunotherapy.
- Challenges and future directions for in vivo applications require further investigation.
