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An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

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High-Speed Radiographic Analysis of Subcutaneous Injection Depots: Dispersion, Morphology, and Diffusion in

Rozhin Derakhshandeh¹, Jean-Christophe Veilleux², Galen H Shi²

¹Department of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA; and rderakhs@purdue.edu.

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Summary

Autoinjector studies reveal drug depots spread significantly beyond the injected volume, primarily expanding horizontally within tissue. This understanding aids in optimizing subcutaneous injection device design and drug absorption prediction.

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Published on: January 21, 2018

Area of Science:

Biomedical Engineering
Pharmaceutics
Drug Delivery Systems

Background:

Autoinjectors enable patient self-administration of subcutaneous medications, offering significant benefits.
Limited experimental data exists on how autoinjector parameters affect drug dispersion and absorption.
Understanding these dynamics is crucial for optimizing drug delivery.

Purpose of the Study:

To investigate the influence of autoinjector injection parameters on subcutaneous plume growth, morphology, and diffusion.
To characterize the real-time dynamics and post-injection depot characteristics.
To provide foundational data for autoinjector design and computational modeling.

Main Methods:

Utilized three commercial autoinjector models with varying volumes (0.5, 1, and 2 mL).
Injected formulations into excised pork belly tissue.
Employed synchrotron radiography for real-time 2D plume visualization and synchrotron CT for 3D post-injection morphology analysis.

Main Results:

Plume growth was nonlinear, with an initial rapid phase followed by slower expansion.
Final plume volume was approximately 25% larger than the delivered dose due to tissue spread.
Plumes expanded predominantly horizontally, with an increasing aspect ratio reaching ~4.
Post-injection diffusion was primarily influenced by tissue properties, not autoinjector design.

Conclusions:

Autoinjector injection parameters significantly influence subcutaneous drug depot characteristics.
The observed horizontal expansion and increased volume highlight the importance of tissue interaction.
Findings support the refinement of autoinjector designs and predictive absorption models for subcutaneous delivery.