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Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction
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The Multifaceted Role of AASDH: From Metabolic Regulation to Cancer and Cardiomyopathies

Jaber H Jaradat1,2,3, Pooya Jalali2,3, Raghad Amro1

  • 1Faculty of Medicine, Mutah University, Al-Karak, Jordan.

Anticancer Research
|August 1, 2025
PubMed

Insights

The enzyme 2-aminoadipic-6-semialdehyde dehydrogenase (AASDH) is vital in metabolism and disease, impacting cancer and heart conditions. Targeting AASDH offers new therapeutic avenues for metabolic modulation in oncology and cardiology.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology
  • Cardiology

Background:

  • The enzyme 2-aminoadipic-6-semialdehyde dehydrogenase (AASDH) is integral to metabolic pathways.
  • AASDH dysregulation is linked to various pathologies, including cancer and cardiomyopathies.
  • Its roles in ATP binding, acid-thiol ligase activity, and stress responses are critical.

Purpose of the Study:

  • To review the multifaceted roles of AASDH in disease.
  • To highlight AASDH's potential as a prognostic biomarker and therapeutic target.
  • To explore AASDH's involvement in metabolic reprogramming and the tumor microenvironment.

Main Methods:

  • Literature review of AASDH's function in cancer and cardiovascular diseases.
  • Analysis of AASDH's molecular mechanisms, including its role in lysine metabolism and oxidative stress.
  • Exploration of AASDH's association with metabolic reprogramming and tumor microenvironment.

Main Results:

  • AASDH is implicated in colorectal cancer (CRC), hepatocellular carcinoma (HCC), and lung adenocarcinoma (LUAD).
  • Genetic alterations in AASDH may affect chemotherapy resistance and tumor progression in MSI-high CRC.
  • AASDH is linked to cardiomyopathies and may serve as a biomarker for heart failure.

Conclusions:

  • AASDH is a significant player in metabolic pathways and disease pathogenesis.
  • Targeting AASDH presents a promising strategy for enhancing cancer and cardiovascular disease therapies.
  • Further understanding of AASDH can lead to novel treatments integrating metabolic modulation with conventional therapies.

Keywords:
AASDHColorectal canceralpha-aminoadipic semialdehyde dehydrogenasemicrosatellite instabilityreview

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