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Updated: Sep 13, 2025

Viral-mediated Labeling and Transplantation of Medial Ganglionic Eminence MGE Cells for In Vivo Studies
Published on: April 23, 2015
The production and functions of caudal ganglionic eminence-derived inhibitory neurons
Emma Horton1, Mercedes F Paredes2
1Department of Neurology, University of California, San Francisco, CA 94143, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA; Developmental and Stem Cell Graduate Program, University of California, San Francisco, CA 94143, USA.
Abstract:
In the brain, maintaining the appropriate levels of excitation and inhibition is required for proper cognitive function. Inhibitory neurons, essential for maintaining this balance and implicated in various neurodevelopmental diseases, are generated during embryonic development from the ganglionic eminences (GEs). This review discusses the importance of inhibitory neuronal subtypes generated from the most posterior GE subregion, the caudal ganglionic eminence (CGE), highlighting what is known about their developmental origins, diversity, and functions in mice, humans, and non-human primates. By reviewing the molecular composition and patterning of the CGE, we discuss how technological advances have provided insights into the spatial heterogeneity of progenitor populations and the distinctive molecular characteristics and functions of CGE-derived neurons.
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