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Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
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Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
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Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
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The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
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Related Experiment Video

Updated: Sep 13, 2025

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
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Substance use disorders: a call for a staging paradigm.

Keren Bachi1,2,3, Yasmin L Hurd1,2,4,5, Edwin A Salsitz6,7

  • 1Addiction Institute of Mount Sinai, New York, NY, USA.

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|August 1, 2025
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Summary

Substance use disorders (SUDs) lack clinical stages like other chronic illnesses. A new dynamic model incorporating social factors could personalize SUD treatment and advance addiction research.

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Area of Science:

  • Neuroscience
  • Public Health
  • Clinical Medicine

Background:

  • Substance use disorders (SUDs) are increasingly recognized as chronic brain disorders.
  • Current characterization lacks distinct clinical stages comparable to other chronic conditions.
  • This gap hinders personalized treatment strategies and clinical application of research findings.

Purpose of the Study:

  • To propose a dynamic, structured staging model for SUDs.
  • To integrate multidimensional factors, including social determinants of health (SDOH), into SUD classification.
  • To enhance personalized treatment approaches and facilitate the clinical translation of addiction research.

Main Methods:

  • Conceptual framework development for a dynamic SUD staging model.
  • Inclusion of diverse factors such as neurobiological, psychological, and social determinants of health.
  • Literature review and synthesis of existing models for chronic disease staging.

Main Results:

  • A proposed multidimensional, dynamic staging model for SUDs.
  • Identification of key factors for staging, including severity, chronicity, and impact of SDOH.
  • Potential for improved patient stratification and tailored interventions.

Conclusions:

  • A dynamic staging model is crucial for advancing SUD clinical management.
  • Integrating SDOH into staging can lead to more equitable and effective care.
  • This framework offers a pathway to enhance personalized addiction medicine and research translation.