Associations between PTSD and pregnancy outcomes: systematic review and Meta- analysis

Area of Science:

• Reproductive Health
• Perinatal Mental Health
• Neonatal Outcomes

Background:

• Post-Traumatic Stress Disorder (PTSD) is a significant mental health condition affecting many women.
• PTSD during pregnancy may be an underlying factor in obstetric complications and adverse neonatal outcomes.

Purpose of the Study:

• To systematically review and meta-analyze the associations between maternal PTSD and pregnancy, obstetric, and neonatal outcomes.

Main Methods:

• A comprehensive literature search was performed across multiple databases (Google Scholar, PubMed, EMBASE).
• Included studies focused on perinatal PTSD and assessed pregnancy, obstetric, and neonatal outcomes.
• Meta-analysis used a random-effects model, with evidence evaluated by GRADE guidelines.

Main Results:

• 40 studies (157,708 pregnancies) were reviewed; 11,750 showed PTSD symptoms.
• Maternal PTSD was associated with smaller infant head circumference, feeding issues, reduced breastfeeding, and lower infant cortisol.
• Meta-analysis revealed increased risks for low birth weight (OR 2.05) and preterm birth (OR 1.23), though evidence quality was low.

Conclusions:

• Pregnancy-related PTSD is associated with adverse maternal and neonatal outcomes.
• Preventing and treating PTSD during pregnancy is essential for maternal, obstetric, and neonatal well-being.
• Further research is needed on the effects of pregnancy treatments for PTSD.