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Drug Biotransformation: Overview01:16

Drug Biotransformation: Overview

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Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
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Principles of Drug Action01:24

Principles of Drug Action

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Drugs are chemical substances that modify biological responses by interacting with macromolecular targets such as receptors, ion channels, transporters, and enzymes. Pharmacodynamics describes the course of action of drugs leading to the physiological effect at a specific site in the body.
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
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Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

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Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
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Drug Therapy01:28

Drug Therapy

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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
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Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
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Prodrugs01:30

Prodrugs

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Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...
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Updated: Sep 13, 2025

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
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How multispecific molecules are transforming pharmacotherapy.

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  • 1Amgen Research, Thousand Oaks, CA, USA. rdii2003@gmail.com.

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Multispecific molecular drugs, designed to engage multiple targets, offer novel therapeutic capabilities beyond traditional single-target drugs. This new class of pharmaceuticals is expanding the possibilities of drug therapy by overcoming biological limitations.

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Area of Science:

  • Pharmacology
  • Drug Discovery
  • Molecular Engineering

Background:

  • Pharmaceutical industry evolved from natural products to engineered molecules targeting specific pathways.
  • Emergence of multispecific molecular drugs in the last 25 years represents a new therapeutic category.
  • These drugs are designed to interact with two or more biological entities for pharmacological effect.

Purpose of the Study:

  • To describe the emergence and impact of multispecific molecular drugs.
  • To highlight how these drugs overcome limitations of traditional therapies.
  • To redefine expectations in pharmacotherapy through advanced drug design.

Main Methods:

  • Review of advancements in drug design and engineering.
  • Analysis of the unique properties and capabilities of multispecific drugs.
  • Discussion of how multispecific drugs circumvent biological barriers.

Main Results:

  • Multispecific drugs exhibit emergent properties not seen in monospecific therapies.
  • These drugs effectively address challenges like rapid clearance and off-target toxicity.
  • A new wave of approved multispecific drugs is demonstrating significant therapeutic potential.

Conclusions:

  • Multispecific molecular drugs represent a paradigm shift in pharmacotherapy.
  • Their prospective design and ability to engage multiple targets unlock new therapeutic avenues.
  • These innovative drugs are recalibrating the potential of pharmaceutical interventions.