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Related Concept Videos

Toxic Reactions: Overview01:26

Toxic Reactions: Overview

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When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
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Types of Toxins01:36

Types of Toxins

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Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
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Effects of Chemicals: Overview01:27

Effects of Chemicals: Overview

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Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable...
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Enhanced Elimination of Poison01:26

Enhanced Elimination of Poison

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Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
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Preclinical Development: Overview01:28

Preclinical Development: Overview

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Related Experiment Video

Updated: Sep 13, 2025

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC
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Patient Centered Outcomes Research in Medical Toxicology.

Rachel Culbreth1, Maryann Mazer-Amirshahi2, Mark B Mycyk3

  • 1Toxicology Investigators Consortium, American College of Medical Toxicology, Phoenix, AZ, USA. Rachel.Culbreth@acmt.net.

Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology
|August 2, 2025
PubMed
Summary

Patient engagement in medical toxicology research enhances evidence quality. The American College of Medical Toxicology (ACMT) promotes involving individuals with lived overdose experiences in research to ensure outcomes are meaningful and trustworthy.

Keywords:
Community participationMedical toxicologyPatient participationPatient-centered outcomes research

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Area of Science:

  • Medical Toxicology
  • Patient-Centered Outcomes Research (PCOR)

Background:

  • Medical toxicology research is shifting towards rigorous methods like randomized controlled trials.
  • Patient engagement is vital for creating trustworthy and meaningful research evidence.

Purpose of the Study:

  • To provide an overview of patient-centered outcomes research (PCOR) in medical toxicology.
  • To guide the integration of patient engagement in toxicology research studies.

Main Methods:

  • Review of current trends in medical toxicology research methodologies.
  • Overview of patient engagement strategies and their application in toxicology.

Main Results:

  • Patient engagement in medical toxicology research is growing.
  • Effective strategies for patient and stakeholder recruitment are essential.
  • Sustainable partnerships are key for successful patient-centered research.

Conclusions:

  • Patient-centered outcomes research (PCOR) is crucial for advancing medical toxicology.
  • Involving patients with lived experiences, particularly from overdose, enhances research relevance.
  • The American College of Medical Toxicology (ACMT) supports patient engagement initiatives.