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Lipoic Acid-Derived Bioadhesive Prepared from Rapid Molecular Aggregation.

Haowei Fang1,2,3, Tao Wang1,3, Yinan Zhu2

  • 1Department of Plastic and Cosmetic Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, P. R. China.

Small (Weinheim an Der Bergstrasse, Germany)
|August 2, 2025
PubMed
Summary

New adhesives utilize supramolecular interactions of alpha-Lipoic acid (LA) for rapid, room-temperature preparation. These LA-based adhesives offer strong adhesion, even underwater, simplifying tissue adhesion applications.

Keywords:
bioadhesivesupramolecular interactionunderwater adhesionwet adhesionα‐lipoic acid

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biomaterials

Background:

  • Alpha-Lipoic acid (LA) based adhesives show promise but face challenges with conditional dependency and long polymerization times.
  • Existing methods require heating and extended cycles, limiting practical applications.

Purpose of the Study:

  • To develop a rapid, room-temperature method for preparing high-performance adhesives using supramolecular interactions of alpha-Lipoic acid (LA) and its derivatives.
  • To investigate the influence of molecular structure and metal ion chelation on adhesive properties.
  • To demonstrate a strategy for creating adhesive patches from non-adhesive materials.

Main Methods:

  • Utilized supramolecular interactions between alpha-Lipoic acid (LA) and amino-modified LA-derivatives in aqueous solutions.
  • Investigated the effect of molecular structure and metal ion chelation on adhesive performance.
  • Developed a "Parasitism" strategy to integrate LA/LA-derivative interactions into polymer porous scaffolds for adhesive patch fabrication.

Main Results:

  • Rapid aggregation of LA and LA-derivatives in water formed adhesives with strong interfacial, underwater, and wet adhesion.
  • Adhesion performance was significantly influenced by the molecular structure of LA-derivatives and metal ion chelation.
  • The "Parasitism" strategy successfully endowed non-adhesive materials with tissue adhesion capabilities.

Conclusions:

  • Supramolecular interactions offer a facile, universal, and scalable method for preparing advanced LA-based adhesives at room temperature.
  • This approach simplifies the creation of tissue-adhesive materials without complex chemical modifications.
  • The developed adhesives demonstrate potential for diverse applications requiring strong and reliable adhesion in wet environments.