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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

280
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
280
Seizures: Classification01:13

Seizures: Classification

593
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
593

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Related Experiment Video

Updated: Sep 13, 2025

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

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Epilepsy Surgery in Tuberous Sclerosis Complex: A TSC Natural History Database Study.

Ajay Gupta1, Honglian Huang1, Nicolas R Thompson2

  • 1Pediatric Epilepsy, Epilepsy Center/Neurological Institute, Cleveland Clinic, Cleveland, Ohio.

Pediatric Neurology
|August 2, 2025
PubMed
Summary

Epilepsy surgery for tuberous sclerosis complex (TSC) in the US often lacks advanced imaging. Resective surgery, particularly single tuber or lobar resections, showed better seizure outcomes than corpus callosotomy (CC).

Keywords:
Corpus callosotomyEpilepsyEpilepsy surgeryHemispherectomyLobectomyTuberectomyTuberous sclerosis complex (TSC)

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Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
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Area of Science:

  • Neurology
  • Neurosurgery
  • Genetics

Background:

  • Epilepsy surgery outcomes in Tuberous Sclerosis Complex (TSC) are primarily known from small tertiary care center series.
  • Generalizability of these findings to the broader epilepsy surgery community remains unclear.

Purpose of the Study:

  • To evaluate epilepsy surgery outcomes in a large, real-world cohort of patients with TSC in the United States.
  • To compare resective epilepsy surgery outcomes with palliative corpus callosotomy (CC).

Main Methods:

  • Data from 2059 patients with TSC were analyzed from the National TSC Natural History Database (TSCNHD).
  • Surgical procedures included tuberectomy/sublobar resection and lobectomy/multilobar resection, compared against CC.
  • Proportional odds logistic regression and Poisson regression analyses were employed.

Main Results:

  • Of 229 patients undergoing epilepsy surgery, common procedures were tuberectomy/sublobar resection (44%) and lobectomy/multilobar resection (40%).
  • Use of advanced imaging like PET, SPECT, and MEG was low (20-29%).
  • Good seizure outcomes were observed in 41% of patients, with resective surgeries showing significantly better outcomes (OR 11.58 for tuberectomy, OR 5.99 for lobectomy) compared to CC.

Conclusions:

  • Epilepsy surgery in TSC in the US frequently omits advanced imaging modalities.
  • Real-world seizure outcomes were lower than previously reported from specialized centers.
  • Single tuber and lobar/multilobar resections were associated with the best seizure outcomes and higher likelihood of antiseizure medication reduction.