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Related Experiment Video

Updated: Sep 13, 2025

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
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Microliter-scale ethanol confinement array with biofluidic triggered release for dual-enhanced precision

Tianyue Ma1, Fei Zhang1, Yumeng Pan1

  • 1Department of Chemistry, College of Sciences, Northeastern University, Shenyang, 110819, China.

Biomaterials
|August 2, 2025
PubMed
Summary

This study presents a novel microneedle array for precise ethanol delivery, enhancing chemotherapy by solubilizing drugs and ablating tumors. This minimally invasive method reduces side effects compared to traditional injections.

Keywords:
Ethanol confinementLiquid microneedle patchMelanomaPrecision chemotherapyTransdermal

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Area of Science:

  • Biomedical Engineering
  • Drug Delivery Systems
  • Cancer Therapy

Background:

  • Ethanol serves as a cost-effective solubilizer for chemotherapeutics and a tumor ablator.
  • Precise control over liquid formulation delivery is essential for accurate dosing and minimizing tissue damage.
  • Current methods face challenges in controlling ethanol volatilization and preventing microbial contamination.

Purpose of the Study:

  • To develop a novel microneedle array system for controlled, localized delivery of ethanol-based chemotherapy.
  • To evaluate the efficacy of this system in solubilizing water-insoluble drugs and ablating tumors.
  • To assess the safety and effectiveness of the system in reducing local and systemic side effects.

Main Methods:

  • Fabrication of a water-dissolvable microneedle array with microliter cavities, resistant to ethanol (APE-PCMN).
  • Sealing the array with an adhesive to prevent ethanol volatilization and microbial invasion.
  • Utilizing paclitaxel (PTX) as a model drug to demonstrate dual solubilization and ablation effects in melanoma treatment.
  • Comparing microliter-scale scattered delivery with traditional intratumoral injection in vivo.

Main Results:

  • The APE-PCMN system effectively prevented ethanol volatilization for up to 7 days and blocked microbial invasion.
  • Dual effects of drug solubilization and locoregional tumor ablation were demonstrated using paclitaxel.
  • Microliter-scale delivery significantly reduced skin necrosis and systemic inflammation compared to intratumoral injection.
  • The system proved effective in inhibiting melanoma growth with two administrations.

Conclusions:

  • The developed biofluidic-responsive, 3D coverable ethanol capsule microarray offers a promising strategy for precision chemotherapy.
  • This microneedle array system provides a detachable, home-friendly, and minimally invasive approach for locoregional drug delivery.
  • The technology enhances therapeutic outcomes by leveraging ethanol's dual properties while improving safety profiles.