Related Experiment Video

Updated: Sep 13, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

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Notch signaling pathway in cervical cancer: From molecular mechanism to therapeutic potential

Jinsha Wang1, Jinjin Zhang1, Ting Wang1

  • 1Department of Pathology, School of Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, Jiangsu 215123, China.

Cellular Signalling
|August 2, 2025
PubMed

Insights

The Notch signaling pathway plays a complex role in cervical cancer, acting as both an oncogene and tumor suppressor. Understanding its mechanisms is key to developing targeted therapies for cervical cancer progression.

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Biology

Background:

  • The Notch signaling pathway is a crucial cell-cell communication system regulating cell functions.
  • In cervical cancer (CC), Notch signaling has context-dependent oncogenic and tumor-suppressive roles.
  • Dysregulated Notch signaling contributes to tumor progression through mechanisms like epithelial-mesenchymal transition (EMT) and therapy resistance.

Purpose of the Study:

  • To comprehensively review the molecular mechanisms of Notch signaling in cervical carcinogenesis.
  • To highlight Notch signaling's role in maintaining cancer stem cells (CSCs) and promoting metastasis.
  • To evaluate emerging Notch-targeted therapeutic strategies for cervical cancer.

Main Methods:

  • Literature review of molecular mechanisms.
  • Analysis of Notch pathway interactions with Wnt and Hippo pathways.
  • Evaluation of clinical data on Notch-targeted therapies.

Main Results:

  • Notch signaling's dual role in cervical cancer is influenced by microenvironment and pathway crosstalk.
  • Dysregulation drives cervical cancer progression via EMT, therapy resistance, and angiogenesis.
  • Notch signaling is critical for maintaining CSCs and promoting metastasis in cervical cancer.

Conclusions:

  • Targeting Notch signaling presents a promising therapeutic avenue for cervical cancer.
  • Further research into Notch pathway modulation could lead to novel treatment strategies.
  • Understanding Notch signaling's complex roles is essential for effective cervical cancer therapy.
Keywords:
Anti-notch therapyCancer stem cell (CSC)Cervical cancer (CC)Epithelial-mesenchymal transition (EMT)Notch pathway

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