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Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
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Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

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Association between asthma and advanced cardiovascular-kidney-metabolic syndrome in U.S. adults, a cross-sectional

Dingyuan Tu1, Shuhui Ju2, Yu Xue3

  • 1Department of Cardiology, The 961th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Qiqihar, 161000, China.

Respiratory Medicine
|August 2, 2025
PubMed

Insights

Asthma is linked to a higher risk of advanced cardiovascular-kidney-metabolic (CKM) syndrome. This study found that individuals with asthma were more likely to have severe CKM syndrome, emphasizing asthma

Area of Science:

  • Cardiology
  • Nephrology
  • Metabolic Health
  • Pulmonology
  • Epidemiology

Background:

  • Cardiovascular-Kidney-Metabolic (CKM) syndrome, a condition recognized for its multisystem nature, was introduced by the American Heart Association in 2023.
  • Chronic airway inflammation in asthma may increase the risk and progression of CKM syndrome stages.

Purpose of the Study:

  • To investigate the association between asthma and advanced stages of CKM syndrome.
  • To determine if asthma is a risk-enhancing factor for severe CKM syndrome.

Main Methods:

  • Cross-sectional study utilizing U.S. adult data from the National Health and Nutrition Examination Survey (2011-2023).
  • Participants were staged 0-4 based on CKM syndrome clinical severity; advanced stages were defined as 3 or 4.
  • Multivariable weighted logistic regression models analyzed the relationship between asthma and advanced CKM syndrome prevalence.

Main Results:

  • A total of 22,394 participants were analyzed, with 3610 having advanced CKM syndrome.
  • After adjusting for covariates, asthma was significantly associated with advanced CKM syndrome (OR, 1.86; 95% CI, 1.59-2.18; p < 0.0001).
  • Subgroup and sensitivity analyses confirmed consistent findings.

Conclusions:

  • Asthma is positively associated with advanced CKM syndrome in the U.S. adult population.
  • These findings underscore the importance of considering asthma as a risk factor for preventing advanced CKM syndrome stages.
Abstract

Keywords:
AsthmaCardiovascular-kidney-metabolic syndromeNational health and nutrition examination survey

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