Practical approaches to cardiac clearance in nontraditional clinical scenarios

Ethan F Kramer1, Jacob C Ricci1, Krunal Shukla2

  • 1College of Medicine, University of Florida, Gainesville, USA.

PubMed

Insights

Clinicians often seek cardiac clearance for procedures without clear guidelines. This review offers management recommendations for six new non-cardiac scenarios, emphasizing a patient-centered approach to cardiovascular risk evaluation.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Medical Decision Making

Background:

  • Many non-cardiac procedures and activities lack established guidelines for cardiovascular risk evaluation.
  • Previous work identified six "nontraditional" requests for cardiovascular risk assessment.
  • The authors continue to receive novel and complex referral requests.

Purpose of the Study:

  • To review the literature and provide management recommendations for six additional "nontraditional" cardiovascular risk evaluation scenarios.
  • To address emerging therapies and activities prompting cardiac clearance inquiries.
  • To guide clinicians in patient-centered cardiovascular risk assessment.

Main Methods:

  • Literature review of existing evidence for specified non-cardiac procedures and activities.
  • Analysis of real-world referral cases received by the authors.
  • Development of management recommendations based on physiological principles and available data.

Main Results:

  • Recommendations are provided for hyperbaric oxygen therapy, ketamine therapy, antipsychotic therapy, and proton therapy to the chest.
  • Cardiovascular risk evaluation considerations for law enforcement officers and bowling are discussed.
  • The need for a standardized, patient-centered approach is reinforced.

Conclusions:

  • A systematic approach to cardiovascular risk evaluation is crucial for diverse clinical scenarios.
  • Understanding the procedure, physiology, and literature is key to informed decision-making.
  • This work expands guidance for "nontraditional" cardiovascular risk evaluations.

Related Concept Videos

Clearance Models: Noncompartmental Models01:17

Clearance Models: Noncompartmental Models

Clearance is a pharmacokinetic parameter traditionally defined by compartment models, signifying the rate at which a drug is expelled from the body. However, a noncompartmental model offers an alternative method for assessing clearance, primarily employing empirical data obtained after administering a single drug dose.
The noncompartmental approach capitalizes on extensive sampling data, correlating the volume of distribution to systemic exposure and the administered dosage. This method enables...
100
Clearance Models: Physiological Models01:09

Clearance Models: Physiological Models

Drug clearance is a critical pharmacokinetic process involving the irreversible removal of drugs from the body through various organs over a specified time period. Physiological models are indispensable in determining organ-specific clearance, defined by the proportion of the drug eliminated per unit of time from the organ's blood volume.
The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's...
120
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
156
Clearance Models: Compartment Models01:25

Clearance Models: Compartment Models

Clearance measures drug elimination from the central compartment, including plasma and highly perfused organs like kidneys and liver. Its calculation varies depending on pharmacokinetic models and administration routes. The one-compartment model, for instance, portrays the pharmacokinetics of polar drugs such as aminoglycoside antibiotics administered intravenously and readily excreted in urine. In this case, clearance is influenced by the terminal rate constant (λz) and the total volume...
130
One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance00:56

One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance

Clearance is a key pharmacokinetic parameter that quantifies the volume of body fluid from which a drug is entirely removed within a specific time frame. It is crucial in assessing how a drug is eliminated from the body and has critical clinical applications.
In the one-compartment open model for intravenous (IV) bolus administration, clearance is estimated by dividing the elimination rate by the plasma drug concentration. This equation leverages the elimination rate constant and the apparent...
140
Drug Elimination: The Concept of Clearance01:06

Drug Elimination: The Concept of Clearance

Drug elimination refers to removing drugs from the body, either through urine by the kidneys or through bile by the liver. Drug clearance is a pharmacokinetic parameter that measures the efficiency of drug removal from the bloodstream within a specific time frame. It is calculated as the rate at which a drug is eliminated from plasma divided by the plasma concentration of the drug.
Drug clearance is not limited to renal excretion but encompasses all organs involved in drug elimination,...
3.0K