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Recent advances in biosensors: structure, principles, classification, and application in bio-manufacturing
Weiguang Gao1, Qi Wang1, Weili Gong1
1Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China; Shandong Provincial Key Laboratory of Biosensors, Jinan 250103, China.
Methods (San Diego, Calif.)
|August 2, 2025
Summary
Biosensors enable real-time monitoring of biochemical information, crucial for advancing intelligent bio-manufacturing. These sensors are vital for precise control and optimization in bioprocesses, driving the bioeconomy forward.
Area of Science:
- Biotechnology
- Bio-manufacturing
- Bioprocess Engineering
Background:
- Bio-manufacturing is a key driver of the bioeconomy, facing challenges in process control due to complex metabolic mechanisms.
- Intelligent bio-manufacturing demands enhanced capabilities for sensing critical biochemical information during production.
Purpose of the Study:
- To review biosensor technology for bio-manufacturing applications.
- To discuss the structure, classification, working principles, and applications of biosensors in bioprocesses.
- To analyze current challenges and future directions for biosensor development in this field.
Main Methods:
- Review of biosensor structures, classifications, and working principles.
- Discussion of biosensor applications in real-time monitoring of biochemical parameters and metabolite concentrations.
- Analysis of challenges and future research trends in biosensor technology for bio-manufacturing.
Main Results:
- Biosensors based on biomolecular recognition offer powerful support for real-time monitoring and precise control of bio-manufacturing processes.
- Applications include monitoring key biochemical parameters, intracellular/extracellular metabolite concentrations, and high-throughput screening.
- Advances in materials, signal conversion, microelectronics, and nanotechnology are improving sensor capabilities.
Conclusions:
- Biosensors are essential tools for the precise control and optimization of bioprocesses in intelligent bio-manufacturing.
- Enhancing biosensor stability and reliability is crucial for widespread adoption.
- Ongoing research focusing on novel components, materials, and integration technologies will further expand their utility in microbial fermentation and biotechnology.
