MicroRNA biosensors for cardiovascular disease detection

Area of Science:

• Biomedical Engineering
• Molecular Diagnostics
• Cardiology

Background:

• Cardiovascular diseases (CVDs) are a leading global cause of mortality.
• Early detection and intervention are critical for improving patient prognosis.
• MicroRNAs (miRNAs) play crucial roles in cardiovascular pathophysiology, acting as potential biomarkers.

Purpose of the Study:

• To review the application of miRNA-based electrochemical biosensors for cardiovascular disease detection.
• To highlight the significance of miRNAs in cardiovascular disorders like myocardial infarction, heart failure, and atherosclerosis.
• To discuss recent advancements in electrochemical biosensor technology for miRNA detection in biological samples.

Main Methods:

• Literature review of studies on miRNA biomarkers and electrochemical biosensors for CVDs.
• Keyword searches in PubMed, Scopus, and Web of Science.
• Analysis of nanomaterial-based electrochemical biosensor integration for miRNA detection.

Main Results:

• Electrochemical biosensors provide rapid, specific, and cost-effective detection of miRNA biomarkers.
• Nanomaterial integration enhances the sensitivity and performance of these biosensors.
• miRNA detection facilitates real-time monitoring of CVD progression and treatment response.

Conclusions:

• miRNA-based electrochemical biosensors show significant promise for early and accurate diagnosis of cardiovascular diseases.
• These biosensors represent a valuable tool for advancing molecular diagnostics in cardiology.
• Further integration of advanced nanomaterials can optimize biosensor performance for clinical applications.