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Updated: Sep 13, 2025

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Medication Safety in Acute Care Settings.

Eduard E Vasilevskis1, Michelle A Chui2, Shiying Mai2

  • 1Division of Hospital Medicine, Department of Medicine, University of Wisconsin, 600 Highland Avenue, K4/484 Clinical Sciences Center, Madison, WI 53792, USA.

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Summary

Medication-related problems in hospitals cause significant harm. Improving medication safety practices, including reconciliation and technology, is crucial to reduce errors and enhance patient safety.

Keywords:
Adverse drug eventsClinical decision supportDrug intensificationDrug shortageMedication discrepanciesMedication reconciliationMedication safetyPolypharmacy

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Area of Science:

  • Healthcare quality and safety
  • Clinical pharmacology
  • Health informatics

Background:

  • Medication-related problems (MRPs) in hospitals lead to substantial preventable harm.
  • Medication errors (ME), adverse drug reactions, and adverse drug events are prevalent, compromising patient safety.
  • Polypharmacy presents significant challenges in managing patient medications.

Purpose of the Study:

  • To address the ongoing issue of medication-related problems in hospital settings.
  • To highlight strategies for improving medication safety and reducing harm.
  • To explore the impact of emerging healthcare trends on medication safety.

Main Methods:

  • Review of current literature on medication safety in hospitals.
  • Analysis of the role of medication reconciliation during care transitions.
  • Examination of technological solutions like clinical decision support systems and AI.
  • Assessment of medication-related effects in novel care models such as Hospital at Home.

Main Results:

  • Medication errors and adverse events remain a significant threat to patient safety.
  • Effective medication reconciliation is vital, particularly during transitions of care.
  • Technological advancements show promise in mitigating medication errors.
  • Emerging healthcare models require careful consideration of medication safety.

Conclusions:

  • Continuous improvement in medication safety practices is essential to minimize preventable harm.
  • A multi-faceted approach involving reconciliation, technology, and adaptive strategies is needed.
  • Addressing polypharmacy and adapting to new care models are key to enhancing patient outcomes.