Vascular age calculation from SCORE2 and SCORE2-OP cardiovascular risk tables

SCORE2 and SCORE2-OP cardiovascular risk tables were published in 2021 and incorporated into European cardiovascular prevention guidelines, replacing the previous SCORE tables. Since the 2012 version of these guidelines, the concept of vascular age has been included. Although there are vascular age tables derived from SCORE, there are no vascular age tables derived from SCORE2 and SCORE2-OP. The aim of this study is to construct new vascular age tables derived from SCORE2 and SCORE2-OP.

Based on the data from the SCORE2 and SCORE2-OP risk tables, 8 regressions between age and risk are calculated in baseline conditions for the 8 combinations of sex and cardiovascular risk zones. Another 248 regressions corresponding to the different non-baseline situations are calculated. By equating the risk in each box of the risk tables with the same risk in baseline conditions, the vascular age in each box of the risk tables can be obtained. Regression, determination and intraclass correlation coefficients are calculated to asses adjustment and agreement.

Four vascular age tables have been obtained corresponding to countries with low, moderate, high and very high cardiovascular risk. The concordance in vascular age between the 4 tables is greater than 0.99, thus a universal vascular age table has been constructed. Vascular age does not need calibration unlike absolute risk.

Vascular age tables have been created from the SCORE2 and SCORE2-OP tables. A single vascular age table may be used for all European Countries.