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Shaping the Future of Personalized Therapy in Bladder Cancer Using Artificial Intelligence
Martina Maggi1, Francesco Chierigo1, Giuseppe Fallara1
1Unit of Urology, Department of Health Science, ASST Santi Paolo and Carlo, University of Milan, Milan, Italy.
European Urology Focus
|August 2, 2025
Summary
Artificial intelligence (AI) offers personalized bladder cancer (BC) management, aiding in detection, treatment, and outcome prediction. Further research is needed to overcome barriers for routine clinical integration of these advanced AI tools.
Area of Science:
- Oncology
- Medical Informatics
- Artificial Intelligence
Background:
- Bladder cancer (BC) is a globally prevalent malignancy, posing significant challenges in patient care and clinical decision-making.
- Current BC management requires enhanced strategies for personalized treatment approaches.
Purpose of the Study:
- To provide an overview of artificial intelligence (AI) applications in various stages of bladder cancer management.
- To highlight AI's potential in developing individualized BC treatment strategies.
- To identify barriers hindering the widespread clinical adoption of AI in BC care.
Main Methods:
- Review of current artificial intelligence (AI) applications, including machine learning and deep learning, in bladder cancer (BC) workflows.
- Exploration of AI's role in BC detection, grading, staging, risk stratification, treatment selection, and outcome prediction.
Main Results:
- AI demonstrates potential for personalizing bladder cancer (BC) management across multiple clinical steps.
- Significant advancements in AI applications for BC are noted, with promising outcomes in various management areas.
- Key barriers remain that impede the broad integration of AI into routine BC clinical practice.
Conclusions:
- Artificial intelligence (AI) tools offer a promising avenue for personalized bladder cancer (BC) care.
- Overcoming existing obstacles is crucial for realizing the full potential of AI-driven BC management.
- Continued research and development are necessary before AI can be widely implemented in clinical settings for BC.

