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Psychosocial factors associated with perceived cognitive functioning in prostate cancer survivors: an exploratory cross-sectional analysis

  • 0Lifespan Health and Wellbeing Research Centre, Macquarie University, New South Wales, 2109, Australia. lorna.huang@mq.edu.au.
Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer +

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August 2, 2025

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August 2, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Functional well-being is key for prostate cancer survivors experiencing cognitive issues. Addressing quality of life and daily activities can help manage cancer-related cognitive impairment (CRCI).

Area Of Science

  • Oncology
  • Psychology
  • Neuroscience

Background

  • Prostate cancer survivorship is increasing, highlighting the need to address concerns like cancer-related cognitive impairment (CRCI).
  • Identifying psychosocial factors is crucial for developing non-pharmacological interventions for CRCI.
  • Prostate cancer survivors (PCS) often experience challenges with cognitive function.

Purpose Of The Study

  • To investigate psychosocial factors associated with perceived cognitive functioning in prostate cancer survivors (PCS).
  • To identify modifiable targets for interventions aimed at improving cognitive function in PCS.

Main Methods

  • A cross-sectional survey was conducted with adult PCS undergoing hormone therapy or active surveillance.
  • Perceived cognitive functioning was assessed using the Perceived Cognitive Impairments subscale (PCI20).
  • Correlations, ANOVAs, and hierarchical regression analyses explored associations between cognitive function and psychosocial factors, controlling for covariates.

Main Results

  • One-third of the 96 respondents reported low cognitive function.
  • Better perceived cognitive functioning correlated with higher physical and functional well-being and lower depression.
  • Functional well-being emerged as the sole significant predictor of perceived cognitive functioning in regression analysis.

Conclusions

  • Perceived cognitive functioning is linked to quality of life and daily activity participation in PCS.
  • A biopsychosocial approach is recommended for developing therapeutic interventions for CRCI.
  • Functional well-being represents a key modifiable factor for addressing CRCI in prostate cancer survivors.

Keywords:

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