Related Experiment Video

Updated: Sep 13, 2025

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients
09:16

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients

Published on: February 28, 2018

7.8K

Cirrhotic cardiomyopathy: a systematic review and meta-analysis of prevalence across various diagnostic approaches

Mohammed Ewid1,2, Suliman Alsagaby3, Abdulsalam Al-Ruqi1

  • 1From the Department of Clinical Sciences, Sulaiman Al Rajhi University College of Medicine, Al Bukaryiah, Saudi Arabia.

Annals of Saudi Medicine
|August 3, 2025
PubMed

Insights

Cirrhotic cardiomyopathy (CCM) prevalence varies significantly based on the diagnostic criteria used. The Montreal 2005 guideline showed higher sensitivity in advanced cirrhosis, while CCC 2019 was better for early stages.

Area of Science:

  • Cardiology
  • Hepatology
  • Medical Diagnostics

Background:

  • Cirrhotic cardiomyopathy (CCM) is a cardiac dysfunction linked to liver cirrhosis.
  • Standardized diagnostic criteria for CCM are lacking, leading to variability in prevalence assessment.

Purpose of the Study:

  • To evaluate the prevalence of cirrhotic cardiomyopathy (CCM) in patients with liver cirrhosis.
  • To compare CCM prevalence across different diagnostic guidelines: Montreal 2005, ASE 2009, and CCC 2019.

Main Methods:

  • Systematic literature search across four databases (PubMed, Embase, Google Scholar, EBSCO).
  • Inclusion of 76 observational studies comprising 7445 patients.
  • Random-effects meta-analysis and subgroup analyses to determine pooled CCM prevalence.

Main Results:

  • Overall pooled CCM prevalence was 48% (95% CI: 44-52%).
  • Prevalence varied by guideline: Montreal 2005 (51%), ASE 2009 (45%), and CCC 2019 (45%).
  • The CCC 2019 criteria were more effective for early-stage cirrhosis (Child-Pugh A), while Montreal 2005 was more sensitive for advanced stages (Child-Pugh C).

Conclusions:

  • CCM prevalence is influenced by the diagnostic criteria and the severity of liver cirrhosis.
  • Further research is required to establish the clinical significance and prognostic implications of each diagnostic criterion for CCM.
Abstract

Keywords:
cardiomyopathiescirrhotic cardiomyopathydiagnosisliver cirrhosisprevalence

More Related Videos

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

5.4K
Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

3.7K

Related Concept Videos

Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
31
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
56
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
48
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
34
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
22
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
58